Subcutaneous administration near the injury site provides both high local concentration and some systemic distribution as the peptide migrates to areas of damage throughout the body
Fibroblasts forming at the fracture site, which create a scaffold structure made of calcium, cartilage, and collagen, develop faster in the presence of the peptide
Copper plays a role in immune regulation, and delivering it through a peptide carrier could fine-tune inflammatory responses more safely than direct metal exposure
Clinical evaluation Tail motor function was scored 8 h and 1, 4, 7, 15, 30, 90, 180, and 360 days after injury (0autotomy
Full therapeutic effects build over 4 to 5 weeks as the medication reaches steady state
PLoS ONE 4 , e6472 (2009)