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Now, next-generation amylin agonists like cagrilintide deliver 10-12% body weight loss with weekly dosing, and when combined with GLP-1s in protocols like CagriSema, produce 15-25% weight loss - approaching bariatric surgery results

AZM, acting potentially as both a senolytic and senomorphic (suppressing IL-6 SASP factor), also showed beneficial effects in a mouse model of endometriosis [55]

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