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Circulating SHBG levels are inversely correlated with markers of non-alcoholic fatty liver disease (NAFLD) and insulin resistance (84)

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Opioids act primarily through -opioid receptors, which are present on leukocytes

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The primary efficacy analysis employed a last-observation-carried-forward approach within a modified intent-to-treat population, which included all participants who had at least one follow-up visit after randomization