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Proponents suggest that lower doses may confer benefits whilst minimising adverse effects, though this approach remains experimental and is not supported by current regulatory approvals

Aydin A, Arsova-Sarafinovska Z, Sayal A, Eken A, Erdem O, Erten K, et al

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A 2009 study, conducted by the European Organisation for Rare Diseases, surveyed 414 families of EDS patients from five countries and found that the average delay to an EDS diagnosis was four years for men but 16 years for women

Some plaintiffs specifically claim they developed gastroparesis, a condition sometimes described as stomach paralysis, after taking the medication as prescribed