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Hormonal Signal Regulation: By activating these central receptors, PT-141 facilitates a targeted response in the downstream hormonal cascades, allowing researchers to observe and map the integrity of the hypothalamic-pituitary-gonadal (HPG) axis

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on the other hand, tumor metabolic plasticity may lead to therapeutic escape, which calls for the development of more selective combinatorial strategies of inhibitors and blockade of compensatory pathways