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On average, semaglutide produces approximately 16-17% total body weight loss and tirzepatide produces approximately 20-22%

Because GLP-1 medications reduce how much you eat, they can lower intake of vitamins A, B12, D, and E, especially in people already at risk due to obesity or type 2 diabetes

[DOI] [PubMed] [Google Scholar] 124.Setter S.M., Iltz J.L., Thams J., Campbell R.K

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To find out the mechanisms behind why Semaglutide has such a potent effect, they injected a florescent version of the drug to determine its uptake into the brain

While this supports weight loss goals, it may also reduce your desire to eat adequate fuel for physical activity