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Genetic heterogeneity The value of focusing on a genetically defined subset The rapid shifts in our understanding of the genetic architecture of developmental neuropsychiatric disorders have led to an emerging picture of substantial etiological heterogeneity

This is a broad assessment of the scientific literature currently available

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Although lifestyle changes are the first line of treatment for obesity, even the most rigorous lifestyle changes typically only produce a 510% weight loss and maintaining weight over time is difficult due to compensatory physiological processes that increase appetite and decrease energy expenditure [134]

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