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Based on the regulation of synaptic plasticity by neurexins, several drugs with potential for sustained antidepressant effect are also discussed

Focus on muscle preservation with protein and resistance training

A typical course is 46 weeks, followed by reassessment

Black cohosh and evening primrose oil remain popular supplements

Note on off-label use: many of the IV protocols described on this page (including NAD+ and high-dose vitamin C) are used off-label, meaning the indication has not been formally approved by a regulatory body for that specific use