Seek urgent medical attention if you experience: Severe abdominal pain , particularly if accompanied by vomiting, fever or jaundice (yellowing of skin/eyes), as this could indicate pancreatitis or gallbladder problemsrare but serious adverse effects requiring immediate assessment Persistent vomiting that prevents adequate fluid intake, which may lead to dehydration and potential kidney problems Severe hypoglycaemia (low blood sugar) with symptoms such as confusion, loss of consciousness or inability to treat yourself For severe symptoms, contact NHS 111, attend A&E, or call 999 if you are severely unwell
What is Sembolic and how does it work
Contact your doctor or pharmacist if they persist or worsen
There is also ongoing investigation into whether GIP co-agonism modulates the nausea and gastrointestinal signalling associated with GLP-1 activation alone
Compounded tirzepatide and semaglutide, dispensed by 503A pharmacies through telehealth platforms, are legal in April 2026 under specific conditions
Quality control Compounded semaglutide production is not directly reviewed by the FDA and the compounding process does not undergo the same rigorous quality testing as FDA-approved medications
