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The latest trials demonstrated weight loss of up to nearly 23 percent of starting body weight - positioning retatrutide as perhaps the most powerful weight loss drug yet developed for adults with heart disease or type 2 diabetes

Retatrutide at 12mg produced approximately 24% weight loss at 48 weeks compared to tirzepatide at 15mg producing approximately 22% at 72 weeks

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An oral form of semaglutide, Rybelsus, is approved for diabetes but requires administration 30 minutes before meals for efficacy (140, 141)