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Sigma-Aldrich, Germany) was administered (127 mg/kg dissolved in saline) via an intraperitoneal (i.p.) route

Examination of inflammatory cells in the kidney has shed light on their connection to fibrosis and provided valuable insights into the pathogenesis of this disease process

359,360 In the diabetic state, abnormalities in cellular energy metabolism affect macrovascular and microvascular lesions, 361,362,363 including abnormalities in substrate delivery to vascular EC or target organ cells (e.g., cardiac myocytes, thylakoid cells in glomeruli, and neurons and Schwann cells in peripheral nerves), conversion of the ratio of cell-specific fuel sources between glucose intermediates, fatty acids, and amino acids, changes in respiratory chain protein function, and uncoupling of respiratory chains

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Groneberg et al., 2002)

Research examining BPC-157 in alkali burn models produced encouraging results