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doi: 10.1016/0092-8674(95)90085-3 24 BylundJCampsallPAMaRCConwayBASpeertDP

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Although most studies suggest that GLP-1RAs promote weight loss mainly due to their inhibitory effect on food intake, other central effects that have been described for native GLP-1 and some GLP-1RAs in rodents and humans encourage future clinical trials to explore additional mechanisms that potentially underlie the beneficial effects observed with this drug class

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Test trials, also known as bellwether trials, are often part of MDL