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When chondrocytes are cultured and expanded for autologous chondrocyte implantation (a cartilage repair procedure), they accumulate senescent cells that reduce the quality of engineered cartilage tissue (Zhu et al., 2021)

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This observation suggests that radial axonal sorting, ensheathment, and potentially metabolic support are ancient glial functions that predate the evolutionary emergence of myelin in jawed vertebrates (Silva et al., 2022