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insulin dose at GLP-1RA initiation was only decreased if HbA1c was below 7.5% ( Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes

10.1074/jbc.R400011200 238 MizgalaH

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IR also allows easier dose adjustments since physicians can increase or decrease individual doses without changing the whole day's coverage

It was discovered in 1973 and has since been studied extensively for its roles in tissue repair, wound healing, and anti-aging applications

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