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33 Exenatide, also a GLP-1 receptor agonist, in a NASH mouse model showed an improvement of mitochondrial tricarboxylic acid cycle flux after a 8-week treatment, a significant decrease in insulin resistance, steatosis, hepatocyte lipotoxicity and hepatic triglyceride content as well as lower expression of hepatic lipogenic genes (Srebp1C, Cd36) and genes involved in inflammation and fibrosis

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It takes 4-5 weeks for its active ingredient, tirzepatide, to reach a level in the blood we call its steady state where its levels remain consistent and stable in the blood

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