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Therefore, we engineered a chimeric protein by fusing GLP-1 to an HSA-binding DARPin with a high affinity for albumin that takes advantage of the extended plasma circulation of HSA to develop a long-acting variant of GLP-1

Oxidative stress-induced necrotic cell death via mitochondira-dependent burst of reactive oxygen species

That is the entire human dataset

Just at reduced bioavailability (approximately 3540% lower than fasted-state dosing)

doi: 10.1056/NEJMoa2004967

It should not be used by individuals with a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer) or those with multiple endocrine neoplasia syndrome type 2 (MEN 2)