And another one that blocks pain, beta endorphin
The American Diabetes Association recommends individualized glucose targets and medication adjustments based on regular monitoring
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Adding an SGLT2 inhibitor to an antidiabetic regimen involving metformin, sulfonylureas, pioglitazone, sitagliptin, or insulin led to a greater A1C reduction without a significant increase in hypoglycemia risk
These benefits appear to reflect both improvements in traditional risk factors - weight, blood pressure, lipid profiles, glycemic control - and potentially direct cardioprotective effects mediated by GLP-1 receptors expressed in cardiomyocytes and vascular endothelium