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Neurobiology of Disease 2008

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"Once the drug is negotiated, it must be featured on formulary in Medicare

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But if androgen receptor density is such a dominant driver of anabolic response, how do you reconcile this with the fact that chronic low-grade inflammation (particularly via IL-6/STAT3 and TNF-/NF-B signaling) can suppress AR nuclear translocation even when receptor count is high and that in some individuals this blunts hypertrophy more dramatically than CAG-repeat length or hormone levels themselves?

Perez-Montes DE, Oca A, Pellitero S, Puig-Domingo M