Bitters are traditionally taken at the beginning of a meal to help the body prepare for digestion
Finally, many exhibit anti-fibrotic and cardiomyocyte-protective actions: they interfere with fibrosis-related pathways (TGF-/Smad, etc.), inhibit cardiac fibroblast activation, and reduce pathological deposition of extracellular matrix in the heart (Xiao et al., 2018
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Citations and Footnotes McKenzie AL, Athinarayanan SJ, McCue JJ, Adams RN, Keyes M, McCarter JP, Volek JS, Phinney SD, Hallberg SJ
10.1177/1078155220904153 164 SnavelyA
The slight acidity of the solution (pH approximately 3.04.0 at 0.1% concentration) protonates basic amino acid residues on poorly water-soluble peptides, increasing their net positive charge and improving electrostatic interaction with the surrounding aqueous solvent a mechanism that dramatically increases the solubility of many lyophilised peptide preparations that resist dissolution in neutral or alkaline aqueous conditions
