doi: 10.3389/fphar.2022.940572 Received 10 May 2022 Accepted 21 June 2022 Published 11 July 2022 Volume 13 - 2022 Edited by Dongmei Li, Georgetown University, United States Reviewed by Oluwafemi Adeleke Ojo, Bowen University, Nigeria Almir Gonalves Wanderley, Federal University of So Paulo, Brazil Updates Copyright 2022 Mthiyane, Dludla, Ziqubu, Mthembu, Muvhulawa, Hlengwa, Nkambule and Mazibuko-Mbeje
Nature, 481 (7381), 385388
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25,26 Furthermore, a polymorphism of the DHFR enzyme resulting in a 19bp deletion within the site of a key regulatory sequence has been theorized to exhibit negative effects on the expression and activity of this enzyme
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