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Mol Chem Neuropathol

K., and Goga, A

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doi: 10.1371/journal.pone.0026998 42 GuabirabaRRodriguesDRMannaPTChollotMSaint-MartinVTrappSet al

Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response in adult male mice

This ensures that phytochemicals, such as curcumin, remain intact during circulation/BBB transit but unleash at disease sites (acidic/inflamed brain regions), amplifying Nrf2/antioxidant effects in AD/PD models with minimal off-target toxicity