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Prescription approval is not guaranteed and depends on individual medical history, eligibility, and provider assessment

Gonzalez-Flecha et al., 1991a, 1991b

In fact, from a database of 186 mutant alleles that are now known, a reasonably clear pattern has emerged (see Table 18-2 )

As the loss of POLRMT results in severe mitochondrial dysfunction in cardiac muscle 70 , a similar mitochondrial dysfunction should occur in beta-cells with the loss or dysfunction of POLRMT, resulting in insulin resistance and diabetes mellitus