[6] First-line pharmacological treatments include phosphodiesterase type 5 (PDE5) inhibitors, which are licensed, well-studied medications: Sildenafil (Viagra): Typically effective within 30-60 minutes, lasting 4-6 hours [7] Tadalafil (Cialis): Longer duration of action (up to 36 hours), also available as daily low-dose formulation [8] Vardenafil (Levitra): Similar efficacy to sildenafil with slightly different pharmacokinetics Avanafil (Spedra): Take approximately 30 minutes before sexual activity
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Experimental observations suggest that it participates in coordinated cellular repair processes by influencing fibroblast activity, modulating angiogenic signaling, and regulating the expression of structural extracellular matrix components such as collagen and elastin
[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Leung C., Hodel A.W., Brennan A.J., Lukoyanova N., Tran S., House C.M., Kondos S.C., Whisstock J.C., Dunstone M.A., Trapani J.A
Frontiers in Endocrinology, 16 , 1520362
No official contraindication exists, as both work through entirely different mechanisms and metabolic pathways
