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In addition, Nrf2 can also regulate the expression of downstream enzymes such as GST and GR, further improving the cell's antioxidant defense network and enabling cells to more effectively respond to damage caused by oxidative stress

Real time-PCR (RT-PCR) results revealed that peroxynitrite treatment caused significant increases in the mRNA expression of proapoptotic genes Bax and P53 , and decreases in the mRNA expression of antiapoptotic genes Bcl2 and Bcl-xL compared with controls (Figure 8D)

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Our data showed that a LOsG diet can lead to ROS accumulation in both blood cells and pancreatic tissues