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"Anti-oxidant and anti-atherogenic properties of liposomal glutathione: Studies in vitro, and in the atherosclerotic apolipoprotein E-defi cient mice."

3.3.2 Fenton reactions and the bidirectional effects of iron homeostasis imbalance Free Fe + participates in the Fenton reaction, leading to the generation of hydroxyl radicals (OH), which represents a crucial step in initiating the lipid peroxidation chain reaction (96)

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Destruction of alveolar walls in emphysematous regions leads to a reduction in the alveolar capillary bed, which diminishes lung elastic recoilforming the core pathological basis for expiratory dyspnea in affected patients ( 4.2.1 Core cell types and their roles Macrophages are key effector cells in emphysema development, degrading elastic fibers of alveolar walls by secreting MMP-9 and MMP-12