Given that this reaction promotes ferroptosis by inducing lipid peroxidation accumulation, blocking the glutaminolysis pathway has been proposed as a potential therapeutic approach for ferroptosis-induced tissue injury
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Cenigaonandia-CampilloASerna-BlascoRGmez-OcaboLSolanes-CasadoSBaos-HerraizNPuerto-NevadoLet alVitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
Treated wounds also show increased collagen deposition and enhanced angiogenesis, with new blood vessel formation supporting healing tissue with improved nutrient delivery