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Women and elderly individuals are particularly susceptible to developing RA, with the reasons for this yet to be fully understood (Lerner and Matthias 2015b)

Though the concept of ADCs is quite simple, successfully developing these magic bullets is rather sophisticated and largely depends on the correct selection of each ADC component as well as the corresponding conjugation chemistry

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The review also documented GSHs role in regenerating vitamin E following detoxification of lipid peroxyl radicals, its involvement in the glyoxalase systems detoxification of dicarbonyl stress induced by methylglyoxal and glyoxal, and its regulation of redox signalling through reversible S-glutathionylation of critical protein cysteine residues

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