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it is not only what happens outside (increased glutamate in the extracellular space) but also inside the cells (metabolism) when glutamate transport falters

Specifically, a fine balance of intracellular spermidine and ROS levels likely determine proliferation, autophagy, differentiation to metacyclic trypomastigote form, as well as antioxidant capacity while the parasite gets ready to enter the mammalian host

E.et al (2022a)

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