Available studies on stacking these two are limited, but theoretically, they target completely different pathways (AMPK activation vs
doi: 10.3389/fimmu.2014.00258 74 JinXBiJ
One of the biggest challenges with glutathione is that it is notoriously difficult to absorb
Notably, fecal microbiota transplantation from individuals with MDD into microbiota-depleted rodents induces depressive-like behaviour, accompanied by elevated plasma KYN and increased KYN/TRP ratios [191]
PMID: 31384691
We expect in the near future growing recognition of GSH involvement, by S -glutathionylation and/or by the thiols redox state shift, not only in the induction of ATG and/or apoptosis, but also in the modulation of activities of molecular/transcription factors such as NEF2L2, PGC1, and p53 that by inducing the antioxidant defense and assuring mitochondrial homeostasis could block both processes