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Sitagliptin has been shown to lower HbA1c level by about 0 } : CS1 maint: overridden setting (link) 1 2 3 4 5 6 7 8 9 10 "Sitagliptin Monograph for Professionals"

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Australian Pharmaceutical Benefits Scheme (PBS): In Australia, a large 10-year study found higher antidepressant use among people on GLP-1 drugs (34% vs 21%), though researchers could not prove a causal connection due to possible confounding factors

Challenges follow patterns at cellular/neurological and systemic levels