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This reduction step occurs via oxidation of GSH to GSSG, and the GSSG is subsequently reduced back to GSH in the body via the enzyme glutathione reductase and NADPH 591

Cross-trial comparisons reveal broadly similar efficacy, with differences in weight reduction and glycemic regulation

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Endocrine 50:405415 Kober K, Olshen A, Conley Y et al (2018) Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors

Notes: IgA, immunoglobulin A

Many features of opioid tolerance can be viewed in terms of the concept of homeostasis, where opioid-responsive neurons adapt to the prolonged presence of opioid receptor activation to normalize net activity