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Furthermore, because the drug still manipulates your metabolic baseline, the risk of rebound weight gain after stopping remains just as real. Several groups should avoid GLP-1s entirely: Those with a personal or family history of medullary thyroid carcinoma or MEN2 Anyone with an active eating disorder Anyone pregnant, breastfeeding, or planning to become pregnant within the next two months (per FDA guidance) Despite how easy it's become to get GLP-1s online via telehealth, a standard prescription model bypasses critical clinical safety guardrails