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Vegans or strict vegetarian diets can be at particular risk of developing a deficiency as non-animal sources of food usually contain no or very low doses of B12

JAMA 323(6):548560 Bai P, Cant C, Oudart H, Brunynszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K (2011) PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation