Nearly 65% on Tirzepatide lost 15% or more versus 40% on Semaglutide
These aggregates can range from small, invisible clusters to visible particles
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A lower BMR means less heat production overall, which can contribute to cold sensitivity, particularly during the first few months of treatment or after a dosage increase
Some people respond better to semaglutide-based drugs, while others may achieve greater success with tirzepatide-based treatments
A secondary analysis also revealed preserved or improved physical function, with a significant reduction in the prevalence of slow gait speed ( 0.35), including IHTG ( p = 0.88 for PCGrimAge, p = 0.36 for PCDNAmTL), suggesting the IHTG association may be marker-specific to DunedinPACE in this pilot analysis (Fig