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Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts

These molecules were tested for DPP-4 inhibitory activity, with 6-methyl-5-(4-methylpyridin-2-yl)-1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4(5H)-one (compound 29) (Figure 5) showing the highest activity (IC 50 = 1.06 M)

Poor hydration on GLP-1s can worsen constipation, nausea, dizziness, and headaches by allowing stool to harden and blood volume to drop

While short-term studies have shown sulforaphane to be safe and well tolerated, evidence around its long-term safety remains limited

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