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Acetylcholinesterase (AChE) is a hydrolase enzyme that breaks down ACh (Figure 1C illustrates this process ( FIGURE 1 The human acetylcholinesterase (huAChE) protein consists of five domains: S1, S2, S3, S4, and the -loop (Figure 1A), with approximate dimensions of 20 in height, 5 in width, and 5 in length (Figure 1B)