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This reaction is wasteful in 2 really important ways

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B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin

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Clinical Nutrition Open Science, 41, 100065

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Doses above 40 mg may cause a depletion in copper and/or iron levels

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Many factors affect the way B12 is absorbed and used in the body, including gut health, age, diet, interference with medications and health conditions

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