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They are prepared by licensed pharmacies following federal and state compounding rules - but they haven't been through the extensive clinical trial process and manufacturing inspections that FDA-approved drugs undergo

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Lastly, keep in mind that most studies showing efficacy of GLP-1 agonists for weight loss usually require participants to make lifestyle modifications such as changes in diet and exercise, to control portions and eat high nutrient, low energy foods and move more while taking the medications

doi: 10.1172/JCI105685 5 McintyreNHoldsworthCDTurnerDS

This investigation applied three absolute dosage levels (1.5, 3.0, 4.5 g/d) in all research participants