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This is a kind of end-product inhibition that prevents the GSH concentration from rising too high

doi: 10.1172/JCI125413 162 LamKCArayaREHuangAChenQDi ModicaMRodriguesRRet al

doi: 10.3389/fphar.2020.590855 Received 03 August 2020 Accepted 18 September 2020 Published 15 October 2020 Volume 11 - 2020 Edited by Efstratios Stratikos, National Centre of Scientific Research Demokritos, Greece Reviewed by Marcin Poreba, Wrocaw University of Science and Technology, Poland Akira Hattori, Kyoto University, Japan Updates Copyright 2020 Hallberg and Larhed

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The pivotal Phase 3 REDEFINE 1 trial showed that participants getting the mix lost an average of 25% of their body weight over 68 weeks, compared to 15.8% with semaglutide 2.4mg alone and just 2.4% with placebo