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Vitamin C: Stimulates collagen synthesis and assists in antioxidant protection against UV-induced photodamage

After entering cells, NADs are often captured by endosomes

However, existing iron chelators exhibit side effects in clinical applications, including gastrointestinal discomfort, hepatotoxicity, and nephrotoxicity ( Based on TfR1-mediated iron uptake and ferroptosis mechanisms, researchers are exploring possibly delaying OA progression by intervening in ferroptosis

Financial support and sponsorship This work was supported by NIH grant R01 AG057381, Ladiges, PI

These obtained nanoparticles, namely TLR2 pep-orid-liposome, loaded of oridonin and TLR2 pep can be enriched on and get internalized in AML cells

And that's been shown in people