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The predicted drug-induced liver injury (DILI) for -carotene is low (Safe for DILI I, Table 5), reflected in a conceptual DILI score of 0.08, while doxorubicin is predicted to be toxic (Toxic for DILI II, Table 5), with a conceptual score near unity ( 0.96), in agreement with clinical observations of anthracycline-induced hepatotoxicity 76

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