The medication also showed improvements in blood pressure and markers of systemic inflammation, suggesting benefits beyond the number on the scale
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Lipid metabolism disorders play a crucial role, with numerous studies confirming alterations in lipid composition in the plasma and brain of patients with AS and depression
Many clinical trials for semaglutide excluded patients with significant gastrointestinal disease, so evidence regarding safety in UC comes primarily from limited observational data and clinical experience
Importantly, GLP-1RAs do not exert direct immunosuppressive effects but instead modulate inflammatory pathways indirectly through metabolic and cellular mechanisms, supporting a favourable safety profile when used alongside bDMARDs