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doi: 10.1016/j.cell.2022.10.007 84 YunnaCMengruHLeiWWeidongC

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The decrease in metabolic capacity causes the accumulation of reactive E 2 metabolites, which further aggravate metabolic disorder ( Progesterone(P) synthesis via multiple pathways, and P itself has antioxidant effects, which may, in certain circumstances, enhance OS and create a vicious cycle