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Given the brains unique susceptibility to proteotoxic stress, owing to its post-mitotic neuronal population, high metabolic demand, and reliance on precise proteome regulation, UPS integrity is indispensable for neuronal survival

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Experimentally, peripheral administration of LPS in animals induces microglial activation and can exacerbate amyloid pathology and neurodegeneration [62]

Metabolic syndrome and cardiometabolic risk factors in the mixed hypercholesterolemic populations with respect to Gender, Age, and obesity in Asir, Saudi Arabia

1 Introduction Graves disease (GD), an autoimmune thyroid disease (AITD), is the most prevalent cause of hyperthyroidism, potentially resulting in goiter, protruding eyeballs, pretibial mucous edema, and an elevated metabolic state, all of which pose significant health risks (1, 2)