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Tirzepatide safety data Tirzepatide safety data comes from the SURPASS and SURMOUNT trial programs involving thousands of subjects
Drug interactions and safety
According to FDA labeling and American Diabetes Association guidance, the risk of hypoglycemia is significantly higher when tirzepatide is used with insulin or sulfonylureas compared to tirzepatide monotherapy
A nationwide Danish retrospective cohort study indicated that GLP-1 RAs may offer protection against lower extremity amputations in patients with T2DM, compared to sulfonylureas [98]
Weighing daily, or multiple times daily, and reacting emotionally to every fluctuation creates a stress response that, as discussed, promotes cortisol-driven weight gain