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Metallothionein and metal binding A second line of defense is metallothionein, a family of small, metal-hungry proteins encoded by genes such as MT1A and MT2A

Moreover, TMAO disrupts the renal tubular transport system by inhibiting organic cation and anion transporters (OCTs and OATs), essential for reabsorbing and secreting various compounds in the kidneys (Samodelov et al., 2020)

Central sensitisation causes distorted pain perception, possibly through facilitation within the spinal cords dorsal horns and the loss of antinociceptive inhibition from the brain