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Finally, while magnesium may theoretically improve insulin sensitivity and glucose metabolism, there is insufficient evidence to suggest that supplementation significantly alters the glycemic efficacy of GLP-1 drugs

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N Engl J Med 1981

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Notably, the subsequent settlement between Novo Nordisk and Hims & Hers (under which Hims & Hers will sell branded FDA-approved semaglutide products while ceasing its advertising of compounded alternatives) suggests that at least some market participants are already adapting to this new reality