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Third, and most relevant to weight loss, tirzepatide dramatically slows gastric emptying

Aim to consume protein-rich, fiber-dense foods during treatment

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The SURMOUNT-1 trial demonstrated up to 22.5% body weight reduction with tirzepatide at the highest dose (15mg weekly), compared to semaglutide's 14.9% in STEP 1

Consequently, it appears that both fALS and sALS astrocytes secrete factors that are toxic to motor neurons, or alternatively do not provide factors needed for motor neuron survival, resulting in cell death

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