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doi: 10.1016/j.brainres.2019.146476 31

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the functional group attacking the amide is a thiol, hydroxyl or amine the resulting molecule may be called a cyclol or, more specifically, a thiacyclol, an oxacyclol or an azacyclol, respectively

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It exists in reduced (GSH) and oxidized (GSSG) forms

That transition is appropriate: the molecular logic is sound, the therapeutic precedents are encouraging, and the unmet need, extending not just lifespan but healthspan, the years lived in full function and vitality, is among the most significant in modern medicine