If you havent heard of Wegovy, you may at least be familiar with Ozempic, its sister medication
GLP-1 receptors are expressed throughout the brain, and their activation promotes neuronal survival, reduces neuroinflammation, and improves synaptic plasticity
Semaglutide can be used in patients who have impaired functioning of insulin and glucagon, but cannot be used as a substitute for insulin
The glucagon receptor raises theoretical concerns about heart rate increases (glucagon is known to increase heart rate), but clinical trial data has not shown significant safety issues in this regard so far
For people who experience severe nausea with injectable semaglutide leading to dehydration and UTI risk, oral formulations might offer a way to continue GLP-1 therapy with a more tolerable side effect profile
These new methods make it easier and more convenient for people to stick with their treatment